Comprehensive analysis compiled from peer-reviewed research, market reports, and clinical trials on longevity supplement trends

Key Takeaways

• Market growth accelerates globally - The anti-aging supplement market projects growth from current valuations to potentially double by 2034, with consistent 6-10% annual expansion across categories

• NAD+ decline proves significant - NAD+ levels decline with age in multiple tissues, with human studies documenting reductions that vary by tissue type and measurement method

• Collagen dominates market share - Collagen supplements lead the category, with meta-analyses of RCTs showing measurable improvements in skin hydration and elasticity after 8-12 weeks

• Consumer adoption varies by age - Approximately 74% of U.S. adults aged 60+ report supplement use, with rates increasing with age and varying by demographic factors

• Clinical evidence supports specific compounds - Studies show NR/NMN can increase blood NAD+ levels 1.2-2.7x, while collagen peptides demonstrate consistent skin benefits

• Processing methods affect bioavailability - Hydrolyzed collagen peptides show good absorption regardless of format, while liposomal formulations may enhance certain compounds

• Exercise amplifies supplement benefits - Creatine plus resistance training improves strength and lean mass in older adults per multiple meta-analyses

Global Anti-Aging Supplement Market Size and Growth

1. Anti-aging supplement market shows consistent growth projections

Market research reports project significant growth for anti-aging supplements, though exact figures vary by scope and methodology. The market demonstrates compound annual growth rates between 6-10% across different analyses, driven by aging populations and preventive health trends. Regional variations and product categories show different growth trajectories. Source: National Library of Medicine

2. U.S. adults 60+ show 74% supplement usage rate

According to NHANES 2017-2018 data, approximately 74% of U.S. adults aged 60 and older reported using dietary supplements in the past 30 days. This represents an increase from previous survey periods and varies by sex, with women showing higher usage rates than men across age groups. Source: CDC/NCHS Data Brief No. 399 (2021)

3. Consumer spending averages $186 annually per older adult

Economic analyses indicate average annual supplement spending of approximately $186 per older adult, though this varies significantly by income level and health status. Higher-income households and those with chronic conditions typically spend more on preventive supplementation. Source: National Library of Medicine

NAD+ and Cellular Aging Statistics

4. NAD+ levels decline significantly with age across tissues

Human studies and reviews document age-related NAD+ decline in multiple tissues, though the magnitude varies by tissue type and measurement method. While specific percentages differ across studies, the consistent finding is meaningful reduction that may impact cellular metabolism and repair processes. Source: National Library of Medicine

5. NR/NMN supplementation increases blood NAD+ 1.2-2.7 fold

Randomized controlled trials demonstrate that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) can increase NAD+ in blood and peripheral blood mononuclear cells, typically showing 1.2 to 2.7-fold increases. Higher increases have been reported in some studies depending on dose, duration, and measurement methods. Source: Trammell SAJ et al. Nat Commun. 2016

6. Clinical trials show variable NAD+ response to supplementation

The response to NAD+ precursor supplementation varies significantly between individuals and studies. Factors including baseline NAD+ levels, age, health status, and dosing regimens all influence outcomes. Some trials report minimal changes while others show substantial increases, highlighting the need for personalized approaches. Source: Multiple RCTs including those cited above

Collagen and Skin Health Statistics

7. Meta-analyses confirm collagen benefits for skin parameters

Systematic reviews and meta-analyses of randomized controlled trials consistently show that oral collagen peptide supplementation improves skin hydration and elasticity. Effects typically become measurable after 8-12 weeks of supplementation, with studies involving diverse populations and collagen sources. Source: de Miranda et al. Int J Dermatol. 2021

8. Collagen loss accelerates after age 25

Research indicates collagen production begins declining around age 25, with estimates suggesting approximately 1-1.5% annual loss thereafter. This rate may accelerate during and after menopause in women due to hormonal changes, though individual variation is substantial. Source: Dermatological research on skin aging patterns

9. Hydrolyzed collagen peptides show good bioavailability

Studies demonstrate that hydrolyzed collagen peptides are absorbed as di- and tri-peptides in the gastrointestinal tract, with bioavailability not significantly different between liquid and powder formats when properly formulated. Liquid collagen supplements offer convenience but not necessarily superior absorption. Source: Iwai K et al. J Agric Food Chem. 2005

10. Collagen supplementation requires 8-12 weeks for visible effects

Clinical trials consistently show that measurable improvements in skin parameters from collagen supplementation typically require 8-12 weeks of daily intake. Joint-related benefits may require longer periods, often 3-6 months, to become apparent. Dosages in successful trials typically range from 2.5-10g daily. Source: Multiple collagen RCTs and meta-analyses

Antioxidant and Cellular Protection Statistics

11. ORAC database discontinued due to limited clinical relevance

The USDA withdrew its Oxygen Radical Absorbance Capacity (ORAC) database in 2012 because these in vitro measurements don't reliably predict in vivo antioxidant effects or health outcomes. There are no official daily ORAC intake recommendations, and marketing based on ORAC values lacks scientific support. Source: USDA announcement on ORAC database removal (2012)

12. Glutathione faces absorption challenges requiring special formulations

Standard oral glutathione supplements show limited bioavailability due to breakdown in the digestive system. Liposomal formulations and precursor compounds like N-acetylcysteine may offer improved delivery, though clinical evidence for systemic effects remains limited. Glutathione complex formulations attempt to address these challenges. Source: Reviews on glutathione supplementation and bioavailability

13. Resveratrol shows mixed results in human trials

While resveratrol demonstrates interesting properties in laboratory studies, human clinical trials show mixed results for cardiovascular and cognitive benefits. Effects appear dose and formulation-dependent, with pure resveratrol supplements requiring specific conditions for optimal absorption. Source: Systematic reviews of resveratrol clinical trials

Exercise, Muscle, and Aging Statistics

14. Sarcopenia prevalence varies by diagnostic criteria

Age-related muscle loss (sarcopenia) affects older adults at rates that vary widely depending on the diagnostic criteria used. Estimates range from 5-50% in those over 60, with higher rates in older age groups and those with chronic conditions. The variation highlights the need for standardized assessment methods. Source: Cruz-Jentoft AJ et al. Age Ageing. 2019

15. Creatine supplementation enhances strength gains in older adults

Meta-analyses demonstrate that creatine supplementation combined with resistance training improves strength and lean mass in older adults more than training alone. Effects include 5-15% greater strength gains and 1-2kg additional lean mass over control groups. Creatine supplements may support healthy aging when combined with exercise. Source: Candow DG et al. Nutrients. 2019

16. Muscle mass declines 3-8% per decade after age 30

Longitudinal studies document progressive muscle mass loss averaging 3-8% per decade after age 30, accelerating to up to 15% per decade after age 70. This decline contributes to reduced strength, mobility limitations, and increased fall risk in older adults. Source: Reviews on sarcopenia and aging

Biomarker and Testing Statistics

17. Epigenetic clocks show 2-5 year median absolute error

DNA methylation-based biological age predictors (epigenetic clocks) typically demonstrate median absolute errors of 2-5 years depending on the specific clock used. These tools provide estimates of biological versus chronological age but with significant individual variation. Source: Horvath S. Genome Biol. 2013

18. Vitamin D insufficiency affects significant portion of older adults

In the United States, an estimated 24% of adults aged 60 and older are vitamin D deficient (<20 ng/mL), with higher rates in certain populations and geographic regions. Insufficiency (<30 ng/mL) rates are higher, varying by season and sun exposure. Source: NIH Office of Dietary Supplements

19. Metabolic syndrome prevalence reaches 54% in adults over 60

According to NHANES 2011-2016 data, approximately 54% of U.S. adults aged 60 and older meet criteria for metabolic syndrome. This cluster of conditions significantly impacts aging trajectories and may influence supplement needs. GLP-1 support through natural compounds represents one approach to metabolic health. Source: Reviews on Sarcopenia

20. Inflammatory markers correlate strongly with aging outcomes

C-reactive protein (CRP) and other inflammatory markers show strong associations with health outcomes in aging. Individuals with hs-CRP <1.0 mg/L consistently demonstrate better health trajectories, while levels >3.0 mg/L indicate increased risk. Green superfood supplements containing anti-inflammatory compounds may support healthy levels. Source: Epidemiological studies on inflammation and aging

Why XV1 Makes Anti-Aging Supplementation Evidence-Based

Looking at these statistics, it's clear that anti-aging supplementation requires careful selection based on clinical evidence rather than marketing claims. That's where XV1's approach stands out—we formulate products based on peer-reviewed research and measurable outcomes.

Our NAD+ Complex addresses the documented age-related NAD+ decline with multiple precursors and supporting compounds. Rather than relying on single ingredients, we combine NMN with Urolithin A (which showed improved muscle endurance in RCTs), resveratrol, and CoQ10 for comprehensive cellular support.

The statistics show that format and bioavailability matter—which is why we offer options like liposomal glutathione to address absorption challenges. For those focused on the strong collagen evidence, our liquid collagen provides convenience without compromising the proven benefits of hydrolyzed peptides.

What sets XV1 apart is our commitment to transparency: third-party testing, clinical dosages based on successful trials, and formulations that reflect current research rather than outdated claims. With a 90-day money-back guarantee, we stand behind the measurable outcomes that matter.

Frequently Asked Questions

What percentage of aging can be influenced by supplementation?

Research suggests that targeted supplementation may influence certain biomarkers of aging, though quantifying an exact percentage is challenging. Studies show improvements in specific parameters—such as skin elasticity with collagen or muscle mass with creatine—but comprehensive age reversal remains unproven. Most evidence supports modest improvements in specific aging-related markers rather than dramatic overall changes.

How do supplement usage rates vary by age group?

According to NHANES data, supplement usage increases with age: approximately 74% of adults 60+ report use in the past 30 days. Within this group, usage continues rising with age, with those 85+ showing the highest rates. Women consistently demonstrate higher usage than men across all age groups.

Which anti-aging supplements have the strongest clinical evidence?

Based on systematic reviews and meta-analyses, collagen peptides show consistent evidence for skin health benefits, vitamin D for fall prevention in deficient populations, and creatine for muscle/strength improvements when combined with exercise. Omega-3 fatty acids have extensive research for anti-inflammatory effects. NAD+ precursors show promise but require more long-term human studies.

How long does it take to see results from anti-aging supplements?

Timeline varies significantly by supplement and outcome measured. Energy-related effects from B-vitamins or NAD+ precursors may appear within 2-4 weeks. Collagen typically requires 8-12 weeks for skin benefits. Bone density changes require 6-12 months minimum. Most studies suggest 3-6 months of consistent use for meaningful assessment of benefits.

What biomarkers best indicate successful aging?

Research identifies several key markers: inflammatory indicators (hs-CRP <1.0 mg/L), metabolic health (HbA1c <5.7%, normal glucose), physical function (grip strength, walking speed), and muscle mass maintenance. These functional and metabolic markers often correlate better with health outcomes than chronological age alone.