List of Supplements Karlie Kloss Takes

A complete breakdown of the science-backed supplements powering the supermodel's wellness routine—and how to build your own.

Karlie Kloss juggles an 18-year modeling career, two young children, her coding education nonprofit Kode With Klossy, and leadership of Bedford Media. That level of output requires more than coffee and willpower. In multiple interviews throughout 2024, the 31-year-old opened up about the specific supplements fueling her daily performance. Her approach centers on what she calls self-care through supplementation: "Being able to take time—even if it's just a minute in the morning to take supplements that are going to be making you feel better all day long—is self-care. I really see supplements as self-care," she told NewBeauty.

Key Takeaways

• Karlie relies on seven core supplements spanning cognitive function, energy production, sleep support, stress management, protein, immunity, and gut health

• Her flagship supplement is a nootropic blend for combating "mom brain fog"—containing ashwagandha backed by 22 clinical trials

• She uses B Complex instead of vitamin IV drips for sustained energy, stating it gives her the same benefits without the time or expense

• Timing matters in her routine—energizing supplements in the morning, calming ones like magnesium at night

• Prebiotic packets are her travel essential for maintaining gut health during frequent trips for work

• 75% of U.S. adults don't meet recommended daily magnesium intake, making her nighttime magnesium habit particularly relevant

Performance and Recovery Essentials

1. B Complex Vitamins

Her daily foundation begins with B Complex vitamins containing all eight B vitamins in their active, tissue-ready forms. Unlike many B vitamins derived from yeast, premium formulas require no conversion by the body, optimizing absorption.

Karlie specifically notes taking B Complex "instead of needing to get" a vitamin drip for energy. For anyone who's priced out vitamin IV services—often $150-300 per session—a daily B complex. She says it gives her an energy boost similar to a vitamin drip—without the time or expense

Why B vitamins work:

• Support cellular energy production through the Krebs cycle

• Help convert food into usable fuel for sustained performance

• Active forms bypass metabolic conversion steps for faster utilization

• Critical for nervous system function and stress response

For those seeking a more comprehensive daily foundation, green superfood powders can deliver B-vitamins, Vitamin C, and dozens of additional nutrients in a single scoop—simplifying the routine while covering more nutritional bases.

2. Whey Protein Isolate

"Protein has been a big, big focus for me as I get older and want to make sure I'm maintaining my strength and conditioning," Karlie explained. Since she doesn't eat meat, supplemental protein becomes even more critical.

Her morning routine often includes a chocolate protein shake—particularly when "running out the door"—delivering around 21 grams of whey isolate per serving.

Protein benefits for active lifestyles:

• Supports muscle maintenance and repair after physical activity

• Helps prevent muscle loss that can occur with aging

• Provides satiety for busy schedules without time for full meals

• Whey isolate offers fast absorption with minimal lactose

For those interested in strength and performance benefits beyond protein, creatine gummies offer muscle-supporting benefits in a convenient, no-shake format—ideal for athletes and busy professionals alike.

Cognitive Function and Mental Clarity

3. Nootropic Blend with Ashwagandha

Karlie's most frequently mentioned supplement is a nootropic blend she credits with addressing postpartum brain fog after having two children in three years.

"After struggling with postpartum brain fog, Kloss now swears by this...for improving cognitive function," PopSugar reported.

The formula contains several evidence-backed ingredients:

• KSM-66 Ashwagandha (300mg): Supported by 22 clinical trials for stress and cognitive benefits

• Ginkgo Phytosome (240mg): Enhanced absorption format for brain circulation support

• Acetyl-L-Carnitine (250mg): Supports cellular energy production in the brain

• Lutein and Zeaxanthin: Filters blue light from screens—relevant for anyone spending hours on digital devices

Karlie notes she's "careful not to take" it too late in the day due to its moderate caffeine content (around 50mg).

For those interested in cellular health and longevity through different mechanisms, compounds like resveratrol support mitochondrial function and cellular repair—addressing age-related decline at a foundational level.

Stress Management and Sleep Support

4. GABA Supplement

GABA (gamma-aminobutyric acid) functions as the brain's chief inhibitory neurotransmitter, promoting calm without sedation. Karlie specifically calls this supplement "really special" and keeps it in regular rotation for stress management.

How GABA supports wellness:

• Promotes relaxation response without drowsiness

• Helps manage stress from demanding schedules

• Supports healthy cortisol patterns

• Works synergistically with magnesium for calm

Managing stress from modeling, business ventures, and motherhood requires tools beyond time management. Research shows that GABA supplementation may support relaxation and stress reduction when taken consistently.

5. Magnesium Bisglycinate

"At night I always take magnesium. They have a really great Magnesium Bisglycinate, which is really great to calm down before bed," Karlie told WWD.

The bisglycinate form binds magnesium to glycine—itself a calming neurotransmitter—making it gentler on digestion than other magnesium forms.

Why magnesium matters:

• Large nutrition surveys suggest a substantial share of U.S. adults don’t meet magnesium requirements (often reported as over half in some NHANES analyses)

• Supports muscle relaxation and recovery

• Critical for sleep quality and stress management

• Deficiency symptoms include poor sleep, muscle cramps, and increased anxiety

The context makes this supplement particularly important for high-performers. Karlie's nighttime magnesium ritual represents a strategic approach to recovery and sleep optimization.

Immune and Gut Health Support

6. Vitamin C with Flavonoids

Listed among the "basics that I love", Vitamin C serves as Karlie's daily immune support. The addition of citrus bioflavonoids enhances absorption and provides greater antioxidant capacity compared to standalone vitamin C supplements.

Vitamin C benefits:

• Supports immune system function year-round

• Acts as powerful antioxidant against oxidative stress

• Supports collagen synthesis for skin and connective tissue

• Bioflavonoids increase bioavailability and effectiveness

The recommended daily intake for vitamin C is 75-90mg for adults, though many wellness-focused individuals consume higher amounts for enhanced immune support.

7. Prebiotic Packets

Gut health forms the foundation of overall wellness, and Karlie prioritizes it—especially during travel. "For those of us who live in New York and are crazy-going, I like to throw their prebiotic in my bag as I'm running out the door," she told NewBeauty.

The portable packets eliminate the friction many people experience with gut health supplements. "You just put it into a glass of water. It's delicious and it's a super easy health hack," she explained.

Why prebiotics matter:

• Feed beneficial gut bacteria that support digestion

• Support nutrient absorption and immune function

• Help maintain gut health during travel stress

• Convenient format increases consistency

For those seeking additional gut health support alongside metabolic benefits, formulas containing berberine, ginger, and plant-based fibers can naturally support healthy digestion while promoting stable blood sugar levels.

Science-Backed Supplement Principles

Karlie's approach reflects several principles worth applying to any supplement routine:

Active ingredient forms matter. Her B Complex uses tissue-ready vitamins requiring no conversion—a detail that separates premium supplements from generic alternatives. Look for methylfolate over folic acid, methylcobalamin over cyanocobalamin.

Third-party testing provides assurance. Quality supplements undergo independent testing for banned substances and label accuracy. This certification matters whether you're a professional athlete or simply someone who values transparency.

Timing optimizes results. Energizing supplements in the morning, calming ones at night. This simple principle maximizes benefits while minimizing potential interference between compounds.

Convenience drives consistency. Karlie's prebiotic packets, her grab-and-go protein shakes, her single-scoop routines—all reflect the reality that the best supplement is the one you'll actually take. Products designed for effortless daily routines remove friction that often derails good intentions.

Building Your Complete Wellness Foundation with XV1

Karlie Kloss's supplement strategy demonstrates a fundamental truth about modern wellness: comprehensive support requires multiple targeted interventions working together. Her seven-supplement routine addresses energy, cognition, sleep, stress, immunity, protein, and gut health—creating a complete foundation rather than relying on any single solution.

This holistic approach aligns perfectly with XV1's philosophy of complete wellness through science-backed supplementation. While Karlie's routine provides an excellent framework, building your own optimal stack requires understanding your unique needs, goals, and lifestyle demands.

Start with your biggest gaps. Most people benefit from beginning with foundational nutrients before adding specialized compounds. XV1 Green Superfood Powder delivers B-vitamins, vitamin C, organic greens, probiotics, and antioxidants in one daily scoop—covering multiple categories Karlie addresses through separate supplements. This vegan, GMO-free formula contains no sugar or fillers and comes with a 90-Day Money Back Guarantee, making it an effortless entry point for comprehensive nutrition.

Layer in performance and recovery support. Once foundational nutrition is covered, adding targeted compounds enhances specific outcomes. XV1 Creatine Gummies provide 1,000mg creatine monohydrate per gummy in a convenient, naturally flavored format—no powder, no mixing, no guesswork. For those prioritizing strength maintenance like Karlie emphasizes, creatine remains one of the most researched performance supplements available, supporting muscle function and exercise capacity.

Address beauty-from-within benefits. Interestingly, Karlie's confirmed stack doesn't include a dedicated collagen product—a potential gap in a routine otherwise focused on comprehensive wellness. XV1 Liquid Collagen delivers hydrolyzed Type I and III collagen peptides, hyaluronic acid, biotin, and zinc in a fast-absorbing sugar-free liquid. Just one tablespoon daily supports joints, skin, hair, and nails—benefits that become increasingly relevant with age and active lifestyles. The liquid format maximizes bioavailability compared to tablets or powders, ensuring nutrients reach where they're needed most.

Optimize cellular health and longevity. Karlie's nootropic contains some antioxidant compounds, but those seeking enhanced cellular protection can benefit from dedicated longevity support. XV1 Resveratrol provides powerful antioxidant defense while supporting cardiovascular health and cognitive performance. Resveratrol activates sirtuins—proteins linked to cellular repair and healthy aging—making it a cornerstone of science-backed longevity protocols.

Support detoxification pathways. Environmental toxins, processed foods, and metabolic byproducts create oxidative stress that can overwhelm the body's natural defenses. XV1 Glutathione Complex delivers what scientists call the body's "master antioxidant." Glutathione supports natural detoxification pathways, promotes liver health, and helps reduce oxidative stress. The liposomal delivery format enhances absorption significantly compared to standard glutathione supplements, ensuring clinical-grade effectiveness.

Design for consistency. The best supplement routine is one you'll actually maintain. XV1 products are specifically formulated for effortless integration into daily life—gummies that taste like real fruit, liquids that mix instantly, powders that blend smoothly. Every product is vegan, non-GMO, and free from artificial additives. Plus, XV1 offers complete subscription flexibility: edit your stack, skip deliveries, or cancel anytime without penalty.

Karlie's philosophy ties her routine together: "These [supplements] give me peace of mind that I'll have the nutrients to make me feel good, both physically and mentally," she told Women's Health. That peace of mind comes from knowing you're addressing your wellness comprehensively—not leaving critical gaps that could undermine your performance, recovery, or long-term health.

Your optimal routine doesn't require seven separate products purchased from multiple brands. XV1's science-backed formulations allow you to cover more nutritional ground with fewer bottles, reducing decision fatigue while maximizing results. Whether you're managing a demanding career, raising a family, pursuing athletic goals, or simply optimizing how you feel daily, complete wellness starts with one consistent step. Choose your foundation, commit to the routine, and let compound consistency deliver the results that temporary motivation never could.

Frequently Asked Questions

What supplements does Karlie Kloss take every day?

Karlie's daily routine includes B Complex vitamins, vitamin C with flavonoids, a nootropic blend with ashwagandha, GABA for stress management, whey protein isolate, prebiotic packets for gut health, and magnesium bisglycinate at night. Her approach prioritizes energy, cognitive function, stress management, and recovery through evidence-backed formulations.

Why do high-profile individuals like Karlie Kloss take supplements?

Demanding schedules create nutritional gaps that diet alone often can't fill. Karlie specifically mentions her supplement routine provides "peace of mind" that she's getting essential nutrients despite a packed calendar. Supplements also allow targeted support for specific needs—like her use of nootropics for cognitive function after experiencing postpartum brain fog.

Are there specific supplements recommended for boosting energy and focus?

B-complex vitamins support cellular energy production, while adaptogens like ashwagandha help the body manage stress that drains focus. For sustained energy without stimulants, green superfood powders offer nutrient-dense support throughout the day. Those seeking cognitive enhancement specifically may benefit from formulas containing ginkgo, acetyl-L-carnitine, and lutein for blue light protection.

What role does gut health play in overall well-being?

The gut influences everything from nutrient absorption to immune function to mood regulation. Research shows the gut microbiome affects multiple body systems. Karlie prioritizes prebiotic support, particularly during travel when routine disruptions can impact digestive health. Prebiotics feed beneficial bacteria that support digestion, immunity, and even mental clarity.

Can supplements truly support anti-aging and cellular repair?

Research supports several compounds for cellular health. Ashwagandha is backed by 22 clinical trials demonstrating stress reduction and cognitive benefits. Resveratrol provides antioxidant protection against cellular damage and activates longevity pathways. Glutathione supports the body's natural detoxification mechanisms. While no supplement reverses aging, evidence-backed compounds can support the body's natural repair mechanisms and promote healthy aging when combined with lifestyle factors like sleep, nutrition, and exercise.